Yes, but not natively in the sense of continuously monitoring a file for changes. Alteryx workflows execute when they’re triggered, so you’ll need an external mechanism to detect file updates and initiate the workflow.

Common approaches include:

• Alteryx Scheduler to run the workflow at regular intervals and process any newly updated files.
• Windows Task Scheduler combined with a PowerShell or batch script that checks the file’s last modified timestamp before launching the workflow.
• Automation platforms such as Power Automate or enterprise orchestration tools, which can trigger an Alteryx workflow when a file is added or updated in a monitored location.

If you’re working in an enterprise environment, Alteryx Server provides more advanced scheduling and workflow automation capabilities, making it easier to manage event-driven or recurring processes.

The best solution depends on your use case. If near real-time processing is required, a file monitoring script or automation platform is usually the most effective option. If a slight delay is acceptable, running the workflow on a scheduled interval is often simpler and easier to maintain.