Yes, you can run tsc --watch and nodemon together using npm scripts. This is a common setup for TypeScript projects because it allows the TypeScript compiler to automatically rebuild your code while nodemon restarts the Node.js application whenever the compiled JavaScript changes.

The easiest way to achieve this is by using a utility such as concurrently or npm-run-all, which lets multiple scripts run in parallel from a single command.

A typical workflow looks like this:

• tsc --watch continuously compiles TypeScript files into JavaScript.
• nodemon watches the compiled output directory (usually dist) and restarts the server whenever a new build is generated.
• Running both together gives you a smooth development experience without manually rebuilding or restarting the application.

A few best practices:

• Configure nodemon to watch the compiled JavaScript output rather than the TypeScript source files.
• Keep your compiled files in a separate directory (such as dist) to avoid unnecessary restarts.
• Enable source maps in your TypeScript configuration if you need easier debugging.
• Exclude folders like node_modules and build artifacts that don’t need to trigger restarts.

If you’re using a newer development setup, you might also consider tools like tsx, ts-node-dev, or nodemon with ts-node, which can execute TypeScript directly and often eliminate the need for a separate compilation step during development.

For most projects, however, running tsc --watch alongside nodemon remains a reliable and widely used workflow because it closely mirrors how the application is built and run in production.